|
KMID : 1188320160100060910
|
|
Gut and Liver
2016 Volume.10 No. 6 p.910 ~ p.916
|
|
|
The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study
|
|
Hong Su-Jin
Park Soo-Heon
Moon Jeong-Seop
Shin Woon-Geon
Kim Jae-Gyu
Lee Yong-Chan
Lee Dong-Ho
Jang Jae-Young
Kim Jae-J.
Lee Hang-Lak
Lee Sang-Woo
Hwangbo Young
Xu Jian Ming
Wang Bang Mao
Xue Zhan Xiong
Liu Fei
Yuan Yao Zong
Leelakusolvong Somchai
Dy Frederick
|
|
|
Abstract
|
|
|
Background/Aims: To investigate the effects of esomeprazole and rebamipide combination therapy on symptomatic improvement in patients with reflux esophagitis.
Methods: A total of 501 patients with reflux esophagitis were randomized into one of the following two treatment regimens: 40 mg esomeprazole plus 300 mg rebamipide daily (combination therapy group) or 40 mg esomeprazole daily (monotherapy group). We used a symptom questionnaire that evaluated heartburn, acid regurgitation, and four upper gastrointestinal symptoms. The primary efficacy end point was the mean decrease in the total symptom score.
Results: The mean decreases in the total symptom score at 4 weeks were estimated to be ?18.1±13.8 in the combination therapy group and ?15.1±11.9 in the monotherapy group (p=0.011). Changes in reflux symptoms from baseline after 4 weeks of treatment were ?8.4±6.6 in the combination therapy group and ?6.8±5.9 in the monotherapy group (p=0.009).
Conclusions: Over a 4-week treatment course, esomeprazole and rebamipide combination therapy was more effective in decreasing the symptoms of reflux esophagitis than esomeprazole monotherapy.
|
|
|
KEYWORD
|
|
|
Peptic esophagitis, Symptoms, Heartburn, Rebamipide, Esomeprazole
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|